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Article

Specific requirement for CD3epsilon in T cell development.

Proceedings of the National Academy of Sciences of the United States of America - 8 Dec 1998

DeJarnette J B, Sommers C L, Huang K, Woodside K J, Emmons R, Katz K, Shores E W, Love P E

Abstract excerpt

T cell antigen receptor (TCR) and pre-TCR complexes are composed of clonotypic heterodimers in association with dimers of signal transducing invariant subunits (CD3gamma, -delta, -epsilon, and zeta). The role of individual invariant subunits in T cell development has been investigated by generating gene-specific mutations in mice. Mutation of CD3gamma, -delta, or zeta results in an incomplete block in...

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Identifiers

PMID: 9843989
DOI: 10.1073/pnas.95.25.14909
PMCID: PMC24549

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Specific requirement for CD3epsilon in T cell development.PMID 9843989Read ↗

Altered T cell development in mice with a targeted mutation of the CD3-epsilon gene.Semantic proximity Read ↗

The CD3gamma chain is essential for development of both the TCRalphabeta and TCRgammadelta lineages.Semantic proximity Read ↗

Normal development and function of natural killer cells in CD3 epsilon delta 5/delta 5 mutant mice.Semantic proximity Read ↗

CD3 delta deficiency arrests development of the alpha beta but not the gamma delta T cell lineage.Semantic proximity Read ↗

Abnormal T cell development in CD3-zeta-/- mutant mice and identification of a novel T cell population in the intestine.Semantic proximity Read ↗

Critical and multiple roles for the CD3epsilon intracytoplasmic tail in double negative to double positive thymocyte differentiation.Semantic proximity Read ↗

The CD3-gammadeltaepsilon and CD3-zeta/eta modules are each essential for allelic exclusion at the T cell receptor beta locus but are both dispensable for the initiation of V to (D)J recombination at the T cell receptor-beta, -gamma, and -delta loci.Semantic proximity Read ↗

The cytoplasmic tail of the T cell receptor CD3 epsilon subunit contains a phospholipid-binding motif that regulates T cell functions.Semantic proximity Read ↗

Targeted disruption within the CD3 zeta/eta/phi/Oct-1 locus in mouse.Semantic proximity Read ↗

Polymorphisms of the T cell receptor CD3delta and CD3epsilon chains affect anti-CD3 antibody binding and T cell activation.Semantic proximity Read ↗

Protein kinase Cepsilon is dispensable for TCR/CD3-signaling.Semantic proximity Read ↗

Preferential requirement of CD3 zeta-mediated signals for development of immature rather than mature thymocytes.Semantic proximity Read ↗

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