Article
Specific requirement for CD3epsilon in T cell development.
Proceedings of the National Academy of Sciences of the United States of America - 8 Dec 1998
DeJarnette J B, Sommers C L, Huang K, Woodside K J, Emmons R, Katz K, Shores E W, Love P E
Abstract excerpt
T cell antigen receptor (TCR) and pre-TCR complexes are composed of clonotypic heterodimers in association with dimers of signal transducing invariant subunits (CD3gamma, -delta, -epsilon, and zeta). The role of individual invariant subunits in T cell development has been investigated by generati...
Topics
- Amino Acid Sequence
- Animals
- CD3 Complex
- Cell Differentiation
- Flow Cytometry
- Immunophenotyping
- Mice
- Molecular Sequence Data
- Mutation
- Receptors, Antigen, T-Cell
- Signal Transduction
- T-Lymphocytes