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Article

The cytoplasmic tail of the T cell receptor CD3 epsilon subunit contains a phospholipid-binding motif that regulates T cell functions.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jul 2009

Deford-Watts Laura M, Tassin Tara C, Becker Amy M, Medeiros Jennifer J, Albanesi Joseph P, Love Paul E, Wülfing Christoph, van Oers Nicolai S C

Abstract excerpt

The CD3 epsilon subunit of the TCR complex contains two defined signaling domains, a proline-rich sequence and an ITAM. We identified a third signaling sequence in CD3 epsilon, termed the basic-rich stretch (BRS). Herein, we show that the positively charged residues of the BRS enable this region of CD3 epsilon to complex a subset of acidic phospholipids, including PI(3)P, PI(4)P, PI(5)P, PI(3,4,5)P(3), and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 19542373
DOI: 10.4049/jimmunol.0900404
PMCID: PMC2954055

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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