Article
Branching out to gain control: how the pre-TCR is linked to multiple functions.
Immunology today - 1 Dec 2000
Kruisbeek A M, Haks M C, Carleton M, Michie A M, Zúñiga-Pflücker J C, Wiest D L
Abstract excerpt
How is signaling specificity achieved by the pre-TCR during selection of T-cell fate? Like the TCR, this receptor controls many functions, and recent studies define which pathways couple the pre-TCR to the molecular events controlling survival, proliferation, allelic exclusion at the TCRbeta locus, and further differentiation.
Topics
- Alleles
- Apoptosis
- Cell Differentiation
- Cell Division
- Cell Survival
- Clonal Deletion
- Gene Expression Regulation
- Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
- Humans
- Lymphocyte Activation
- Membrane Glycoproteins