The CD3-gammadeltaepsilon and CD3-zeta/eta modules are each essential for allelic exclusion at the T cell receptor beta locus but are both dispensable for the initiation of V to (D)J recombination at the T cell receptor-beta, -gamma, and -delta loci.

doi:10.1084/jem.187.1.105

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Article

The CD3-gammadeltaepsilon and CD3-zeta/eta modules are each essential for allelic exclusion at the T cell receptor beta locus but are both dispensable for the initiation of V to (D)J recombination at the T cell receptor-beta, -gamma, and -delta loci.

The Journal of experimental medicine - 5 Jan 1998

Ardouin L, Ismaili J, Malissen B, Malissen M

Abstract excerpt

The pre-T cell receptor (TCR) associates with CD3-transducing subunits and triggers the selective expansion and maturation of T cell precursors expressing a TCR-beta chain. Recent experiments in pre-Talpha chain-deficient mice have suggested that the pre-TCR may not be required for signaling alle...

Topics

Alleles
Animals
Base Sequence
DNA Nucleotidyltransferases
DNA Primers
Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
Gene Rearrangement, delta-Chain T-Cell Antigen Receptor
Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor
Genes, RAG-1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mice, Knockout

Mice, Transgenic

Models, Biological

Receptor-CD3 Complex, Antigen, T-Cell

Receptors, Antigen, T-Cell, alpha-beta

Recombination, Genetic

Signal Transduction

T-Lymphocyte Subsets

Source

Open in PubMed Open full text

Identifiers

PMID: 9419216
DOI: 10.1084/jem.187.1.105
PMCID: PMC2199187

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9419216-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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The CD3-gammadeltaepsilon and CD3-zeta/eta modules are each essential for allelic exclusion at the T cell receptor beta locus but are both dispensable for the initiation of V to (D)J recombination at the T cell receptor-beta, -gamma, and -delta loci.PMID 9419216Read ↗

Altered T cell development in mice with a targeted mutation of the CD3-epsilon gene.Semantic proximity Read ↗

Regulation of T cell receptor (TCR) beta gene expression by CD3 complex signaling in immature thymocytes: implications for TCRbeta allelic exclusion.Semantic proximity Read ↗

Allelic exclusion in pTalpha-deficient mice: no evidence for cell surface expression of two T cell receptor (TCR)-beta chains, but less efficient inhibition of endogeneous Vbeta--> (D)Jbeta rearrangements in the presence of a functional TCR-beta transgene.Semantic proximity Read ↗

Specific requirement for CD3epsilon in T cell development.Semantic proximity Read ↗

The CD3gamma chain is essential for development of both the TCRalphabeta and TCRgammadelta lineages.Semantic proximity Read ↗

The Ets-1 transcription factor is required for complete pre-T cell receptor function and allelic exclusion at the T cell receptor beta locus.Semantic proximity Read ↗

TCRbeta transmembrane tyrosines are required for pre-TCR function.Semantic proximity Read ↗

Function of the pre-T-cell receptor alpha chain in T-cell development and allelic exclusion at the T-cell receptor beta locus.Semantic proximity Read ↗

Regulation of T cell receptor (TCR)-beta locus allelic exclusion and initiation of TCR-alpha locus rearrangement in immature thymocytes by signaling through the CD3 complex.Semantic proximity Read ↗

Crucial function of the pre-T-cell receptor (TCR) in TCR beta selection, TCR beta allelic exclusion and alpha beta versus gamma delta lineage commitment.Semantic proximity Read ↗

GATA3 Abundance Is a Critical Determinant of T Cell Receptor β Allelic Exclusion.Semantic proximity Read ↗

Targeted disruption within the CD3 zeta/eta/phi/Oct-1 locus in mouse.Semantic proximity Read ↗

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