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Article

Loss of TACI causes fatal lymphoproliferation and autoimmunity, establishing TACI as an inhibitory BLyS receptor.

Immunity - 1 Feb 2003

Seshasayee Dhaya, Valdez Patricia, Yan Minhong, Dixit Vishva M, Tumas Daniel, Grewal Iqbal S

Abstract excerpt

BLys , a key cytokine that sustains B cell maturation and tolerance, binds three receptors: BR3, BCMA, and TACI. Results from knockout mice implicate a major functional role for BR3 and a redundant one for BCMA in B cell function. TACI's role is controversial based on defects in TI antibody responses accompanied by B cell hyperplasia in knockout mice. We have presently characterized a precise role for TACI in...

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Identifiers

PMID: 12594954
DOI: 10.1016/s1074-7613(03)00025-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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