Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Regulation of T cell receptor (TCR) beta gene expression by CD3 complex signaling in immature thymocytes: implications for TCRbeta allelic exclusion.

Proceedings of the National Academy of Sciences of the United States of America - 30 Mar 1999

Biro J, Würch A, Potocnik A J, Falk I, Mossmann H, Eichmann K

Abstract excerpt

During alphabeta thymocyte development, clonotype-independent CD3 complexes are expressed at the cell surface before the pre-T cell receptor (TCR). Signaling through clonotype-independent CD3 complexes is required for expression of rearranged TCRbeta genes. On expression of a TCRbeta polypeptide chain, the pre-TCR is assembled, and TCRbeta locus allelic exclusion is established. We investigated the putative...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Genetically Modified
Share to Gene Rearrangement, beta-Chain T-Cell Antigen Receptor

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, T-Cell Receptor beta

Share to Lymphocyte Specific Protein Tyrosine Kinase p56(lck)

Share to Mice, Knockout

Share to Receptors, Antigen, T-Cell, alpha-beta

Share to Reverse Transcriptase Polymerase Chain Reaction

Share to T-Lymphocytes

Source

Open in PubMed Open full text

Identifiers

PMID: 10097132
DOI: 10.1073/pnas.96.7.3882
PMCID: PMC22389

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Regulation of T cell receptor (TCR) beta gene expression by CD3 complex signaling in immature thymocytes: implications for TCRbeta allelic exclusion.PMID 10097132Read ↗

GATA3 Abundance Is a Critical Determinant of T Cell Receptor β Allelic Exclusion.Semantic proximity Read ↗

Allelic exclusion in pTalpha-deficient mice: no evidence for cell surface expression of two T cell receptor (TCR)-beta chains, but less efficient inhibition of endogeneous Vbeta--> (D)Jbeta rearrangements in the presence of a functional TCR-beta transgene.Semantic proximity Read ↗

Regulation of T cell receptor (TCR)-beta locus allelic exclusion and initiation of TCR-alpha locus rearrangement in immature thymocytes by signaling through the CD3 complex.Semantic proximity Read ↗

The CD3-gammadeltaepsilon and CD3-zeta/eta modules are each essential for allelic exclusion at the T cell receptor beta locus but are both dispensable for the initiation of V to (D)J recombination at the T cell receptor-beta, -gamma, and -delta loci.Semantic proximity Read ↗

Regulation of TCR alpha and beta gene allelic exclusion during T-cell development.Semantic proximity Read ↗

Receptor-specific allelic exclusion of TCRV alpha-chains during development.Semantic proximity Read ↗

TCRbeta transmembrane tyrosines are required for pre-TCR function.Semantic proximity Read ↗

Protein tyrosine kinase p56lck controls allelic exclusion of T-cell receptor beta-chain genes.Semantic proximity Read ↗

Allelic exclusion at the TCRbeta locus.Semantic proximity Read ↗

Posttranscriptional silencing of VbetaDJbetaCbeta genes contributes to TCRbeta allelic exclusion in mammalian lymphocytes.Semantic proximity Read ↗

The CD3gamma chain is essential for development of both the TCRalphabeta and TCRgammadelta lineages.Semantic proximity Read ↗

Immature thymocytes employ distinct signaling pathways for allelic exclusion versus differentiation and expansion.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.