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Article

The CD3gamma chain is essential for development of both the TCRalphabeta and TCRgammadelta lineages.

The EMBO journal - 1 Apr 1998

Haks M C, Krimpenfort P, Borst J, Kruisbeek A M

Abstract excerpt

CD3gamma and CD3delta are the most closely related CD3 components, both of which participate in the TCRalphabeta-CD3 complex expressed on mature T cells. Interestingly, however, CD3delta does not appear to participate functionally in the pre-T-cell receptor (TCR) complex that is expressed on immature T cells: disruption of CD3delta gene expression has no effect on the developmental steps controlled by the...

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Identifiers

PMID: 9524111
DOI: 10.1093/emboj/17.7.1871
PMCID: PMC1170534

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