Article
The CD3gamma chain is essential for development of both the TCRalphabeta and TCRgammadelta lineages.
The EMBO journal - 1 Apr 1998
Haks M C, Krimpenfort P, Borst J, Kruisbeek A M
Abstract excerpt
CD3gamma and CD3delta are the most closely related CD3 components, both of which participate in the TCRalphabeta-CD3 complex expressed on mature T cells. Interestingly, however, CD3delta does not appear to participate functionally in the pre-T-cell receptor (TCR) complex that is expressed on imma...
Topics
- Animals
- B-Lymphocytes
- CD3 Complex
- CD4 Antigens
- CD8 Antigens
- Cell Lineage
- Gene Rearrangement, T-Lymphocyte
- Lymph Nodes
- Mice
- Mice, Knockout
- Organ Culture Techniques
- Phenotype
- RNA, Messenger
- Receptors, Antigen, T-Cell, alpha-beta
- Receptors, Antigen, T-Cell, gamma-delta
- Spleen
- T-Lymphocytes
- Thymus Gland