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Article

TCRbeta transmembrane tyrosines are required for pre-TCR function.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jan 2002

Spain Lisa M, Liu Pinghu

Abstract excerpt

The pre-TCR promotes thymocyte development in the alphabeta lineage. Productive rearrangement of the TCRbeta locus triggers the assembly of the pre-TCR, which includes the pTalpha chain and CD3 epsilongammadeltazeta subunits. This complex receptor signals the up-regulation of CD4 and CD8 expression, thymocyte proliferation/survival, and the cessation of TCRbeta rearrangements (allelic exclusion). In this study,...

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Source

Identifiers

PMID: 11751955
DOI: 10.4049/jimmunol.168.1.127

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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