Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Alteration of p53 pathway in squamous cell carcinoma of the head and neck: impact on treatment outcome in patients treated with larynx preservation intent.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Jul 2002

Osman Iman, Sherman Eric, Singh Bhuvanesh, Venkatraman Ennapadam, Zelefsky Michael, Bosl George, Scher Howard, Shah Jatin, Shaha Ashok, Kraus Dennis, Cordon-Cardo Carlos, Pfister David G

Abstract excerpt

PURPOSE: To identify the role of p53 pathway alteration(s) as predictors of treatment outcome in patients with advanced, resectable, squamous cell carcinoma (SCC) of the larynx and pharynx treated with larynx preservation (LP) intent. PATIENTS AND METHODS: Seventy-one patients treated on two consecutive LP protocols were studied based on availability of representative tissues. We analyzed the expression pattern...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Squamous Cell
Share to Head and Neck Neoplasms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Immunophenotyping

Share to Laryngeal Neoplasms

Share to Multivariate Analysis

Share to Predictive Value of Tests

Share to Proportional Hazards Models

Share to Survival Analysis

Source

Identifiers

PMID: 12089228
DOI: 10.1200/JCO.2002.06.161

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Alteration of p53 pathway in squamous cell carcinoma of the head and neck: impact on treatment outcome in patients treated with larynx preservation intent.PMID 12089228Read ↗

Overexpression of p53 predicts organ preservation using induction chemotherapy and radiation in patients with advanced laryngeal cancer. Department of Veterans Affairs Laryngeal Cancer Study Group.Semantic proximity Read ↗

Loss of MTBP expression is associated with reduced survival in a biomarker-defined subset of patients with squamous cell carcinoma of the head and neck.Semantic proximity Read ↗

Head and neck tumor sites differ in prevalence and spectrum of <i>p53</i> alterations but these have limited prognostic valueSemantic proximity Read ↗

The p53 network in head and neck cancer.Semantic proximity Read ↗

Patterns of p53 gene mutations in head and neck cancer: full-length gene sequencing and results of primary radiotherapy.Semantic proximity Read ↗

How phenotype guides management of non-conventional squamous cell carcinomas of the larynx?Semantic proximity Read ↗

Relationship between molecular markers and treatment response in a retrospective cohort of Indian patients with primary carcinoma of the larynx.Semantic proximity Read ↗

Classification of TP53 mutations and HPV predict survival in advanced larynx cancer.Semantic proximity Read ↗

P53 alteration in oral tongue cancer is not significantly associated with age at diagnosis or tobacco exposure.Semantic proximity Read ↗

The prognostic value of TP53 mutations in hypopharyngeal squamous cell carcinoma.Semantic proximity Read ↗

TP53 and head and neck neoplasms.Semantic proximity Read ↗

Alterations of the p14ARF-p53-MDM2 pathway in oral squamous cell carcinoma: MDM2 overexpression is a common event.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.