Article
Overexpression of p53 predicts organ preservation using induction chemotherapy and radiation in patients with advanced laryngeal cancer. Department of Veterans Affairs Laryngeal Cancer Study Group.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery - 1 Oct 1995
Bradford C R, Zhu S, Wolf G T, Poore J, Fisher S G, Beals T, McClatchey K D, Carey T E
Abstract excerpt
A critical research frontier in head and neck oncology involves defining the use of induction chemotherapy regimens to allow organ preservation and to avoid functionally debilitating surgical resections. Completed clinical trials in laryngeal cancer indicate that such an approach is feasible, but progress thus far has been limited by our inability to predict which patients are likely to respond to chemotherapy...
Topics
- Antimetabolites, Antineoplastic
- Antineoplastic Combined Chemotherapy Protocols
- Carcinoma, Squamous Cell
- Cell Division
- Cisplatin
- Combined Modality Therapy
- Drug Resistance, Neoplasm
- Fluorouracil