Article
The p53 network in head and neck cancer.
Oral oncology - 1 Apr 2003
Gasco Milena, Crook Tim
Abstract excerpt
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide and, despite advances in treatment, still represents a clinical challenge. Inactivation of one or more components of the p53 network is an extremely common event in human neoplasia. In HNSCC, disabling of p53 occurs in a high proportion of cases by mutation in the p53 gene, but other mechanisms of inactivation, such as the...
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