Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Classification of TP53 mutations and HPV predict survival in advanced larynx cancer.

The Laryngoscope - 1 Sept 2016

Scheel Adam, Bellile Emily, McHugh Jonathan B, Walline Heather M, Prince Mark E, Urba Susan, Wolf Gregory T, Eisbruch Avraham, Worden Francis, Carey Thomas E, Bradford Carol

Abstract excerpt

OBJECTIVES/HYPOTHESIS: Assess tumor suppressor p53 (TP53) functional mutations in the context of other biomarkers in advanced larynx cancer. STUDY DESIGN: Prospective analysis of pretreatment tumor TP53, human papillomavirus (HPV), Bcl-xL, and cyclin D1 status in stage III and IV larynx cancer patients in a clinical trial. METHODS: TP53 exons 4 through 9 from 58 tumors were sequenced. Mutations were grouped using...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genes, p53
Share to Laryngeal Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Papillomaviridae

Share to Prognosis

Share to Survival Rate

Source

Open in PubMed Open full text

Identifiers

PMID: 27345657
DOI: 10.1002/lary.25915
PMCID: PMC5002993

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Classification of TP53 mutations and HPV predict survival in advanced larynx cancer.PMID 27345657Read ↗

Mutation patterns and evolutionary action score of TP53 enable identification of a patient population with poor prognosis in advanced non-small cell lung cancer.Semantic proximity Read ↗

Functionally impactful TP53 mutations are associated with increased risk of extranodal extension in clinically advanced oral squamous cell carcinoma.Semantic proximity Read ↗

Evaluating the prognostic significance of p53 and TP53 mutations in HPV-negative hypopharyngeal carcinoma patients: a 5-year follow-up retrospective study.Semantic proximity Read ↗

The prognostic value of TP53 mutations in hypopharyngeal squamous cell carcinoma.Semantic proximity Read ↗

High-risk TP53 mutations predict poor primary treatment response of patients with head and neck squamous cell carcinoma.Semantic proximity Read ↗

Prognostic value of p53 mutations in oesophageal adenocarcinoma: final results of a 15-year prospective study.Semantic proximity Read ↗

Predicting survival in head and neck squamous cell carcinoma from TP53 mutation.Semantic proximity Read ↗

Relationships between p53 mutation, HPV status and outcome in oropharyngeal squamous cell carcinoma.Semantic proximity Read ↗

Evolutionary Action Score of TP53 Identifies High-Risk Mutations Associated with Decreased Survival and Increased Distant Metastases in Head and Neck Cancer.Semantic proximity Read ↗

Alteration of p53 pathway in squamous cell carcinoma of the head and neck: impact on treatment outcome in patients treated with larynx preservation intent.Semantic proximity Read ↗

Head and neck tumor sites differ in prevalence and spectrum of <i>p53</i> alterations but these have limited prognostic valueSemantic proximity Read ↗

The spectrum of mutations in TP53 in laryngeal cancer patients from a high-incidence population shows similarities to many of the known mutational hotspots.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.