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Article

Fission yeast chk1 mutants show distinct responses to different types of DNA damaging treatments.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Jul 2002

Francesconi Stefania, Smeets Monique, Grenon Muriel, Tillit Jeanne, Blaisonneau Joël, Baldacci Giuseppe

Abstract excerpt

BACKGROUND: Chk1 kinase is activated by phosphorylation at serine-345 by Rad3 checkpoint kinase and is required for DNA damage checkpoint in late S and G2 phase of S. pombe cell cycle. We studied the ability of two chk1 mutants, chk1-1 and chk1-2, to undergo phosphorylation and to delay cell cycle progression in response to different types of DNA lesions. RESULTS: Both the Chk1-1 and Chk1-2 mutant proteins are...

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Identifiers

PMID: 12081644
DOI: 10.1046/j.1365-2443.2002.00552.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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