Article
The S/M checkpoint at 37 degrees C and the recovery of viability of the mutant poldeltats3 require the crb2+/rhp9+ gene in fission yeast.
Molecular & general genetics : MGG - 1 Jan 1999
Grenon M, Tillit J, Piard K, Baldacci G, Francesconi S
Abstract excerpt
We have isolated a mutant in fission yeast, in which mitosis is uncoupled from completion of DNA replication when DNA synthesis is impaired by a thermosensitive mutation in the gene encoding the catalytic subunit of DNA polymerase delta. By functional complementation, we cloned the wild-type gene...
Topics
- Cell Cycle Proteins
- Checkpoint Kinase 1
- Checkpoint Kinase 2
- DNA Damage
- DNA Polymerase III
- DNA Replication
- Fungal Proteins
- Gene Deletion
- Hydroxyurea
- Mitosis
- Mutation
- Nuclear Proteins
- Protein Kinases
- Protein Serine-Threonine Kinases
- S Phase
- Schizosaccharomyces
- Schizosaccharomyces pombe Proteins
- Temperature