Article
Analysis of Rad3 and Chk1 protein kinases defines different checkpoint responses.
The EMBO journal - 15 Dec 1998
Martinho R G, Lindsay H D, Flaggs G, DeMaggio A J, Hoekstra M F, Carr A M, Bentley N J
Abstract excerpt
UNLABELLED: Eukaryotic cells respond to DNA damage and S phase replication blocks by arresting cell-cycle progression through the DNA structure checkpoint pathways. In Schizosaccharomyces pombe, the Chk1 kinase is essential for mitotic arrest and is phosphorylated after DNA damage. During S phase...
Topics
- Adenosine Triphosphatases
- Amino Acid Sequence
- Checkpoint Kinase 1
- Checkpoint Kinase 2
- DNA Damage
- DNA Helicases
- DNA Replication
- G2 Phase
- Gene Dosage
- Hydroxyurea
- Interphase
- Molecular Sequence Data
- Mutation
- Phosphorylation
- Protein Binding
- Protein Kinases
- Protein Serine-Threonine Kinases
- Radiation Tolerance