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Article

Analysis of Rad3 and Chk1 protein kinases defines different checkpoint responses.

The EMBO journal - 15 Dec 1998

Martinho R G, Lindsay H D, Flaggs G, DeMaggio A J, Hoekstra M F, Carr A M, Bentley N J

Abstract excerpt

UNLABELLED: Eukaryotic cells respond to DNA damage and S phase replication blocks by arresting cell-cycle progression through the DNA structure checkpoint pathways. In Schizosaccharomyces pombe, the Chk1 kinase is essential for mitotic arrest and is phosphorylated after DNA damage. During S phase, the Cds1 kinase is activated in response to DNA damage and DNA replication blocks. The response of both Chk1 and Cds1...

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Source

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Identifiers

PMID: 9857181
DOI: 10.1093/emboj/17.24.7239
PMCID: PMC1171070

Genes

ATM
ATR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Analysis of Rad3 and Chk1 protein kinases defines different checkpoint responses.PMID 9857181Read ↗

rad-dependent response of the chk1-encoded protein kinase at the DNA damage checkpoint.Semantic proximity Read ↗

S-phase-specific activation of Cds1 kinase defines a subpathway of the checkpoint response in Schizosaccharomyces pombe.Semantic proximity Read ↗

The Schizosaccharomyces pombe S-phase checkpoint differentiates between different types of DNA damage.Semantic proximity Read ↗

The activation loop residue serine 173 of <i>S.pombe</i> Chk1 kinase is critical for the response to DNA replication stressSemantic proximity Read ↗

Interaction of 14-3-3 protein with Chk1 affects localization and checkpoint function.Semantic proximity Read ↗

Delineating the position of rad4+/cut5+ within the DNA-structure checkpoint pathways in Schizosaccharomyces pombe.Semantic proximity Read ↗

Fission yeast chk1 mutants show distinct responses to different types of DNA damaging treatments.Semantic proximity Read ↗

Identification and characterization of new elements involved in checkpoint and feedback controls in fission yeast.Semantic proximity Read ↗

The chk1 pathway is required to prevent mitosis following cell-cycle arrest at 'start'.Semantic proximity Read ↗

Checking in on Cds1 (Chk2): A checkpoint kinase and tumor suppressorSemantic proximity Read ↗

Fission yeast chk1 protein kinase links the rad checkpoint pathway to cdc2.Semantic proximity Read ↗

Chk1 activation requires Rad9 S/TQ-site phosphorylation to promote association with C-terminal BRCT domains of Rad4TOPBP1.Semantic proximity Read ↗

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