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The topoisomerase I poison camptothecin generates a Chk1-dependent DNA damage checkpoint signal in fission yeast.

Yeast (Chichester, England) - 1 Jul 1999

Wan S, Capasso H, Walworth N C

Abstract excerpt

The protein kinase Chk1 is essential for the DNA damage checkpoint. Cells lacking Chk1 are hypersensitive to DNA-damaging agents such as UV light and gamma-irradiation because they fail to arrest the cell cycle when DNA damage is generated. Phosphorylation of Chk1 occurs after DNA damage and is d...

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Camptothecin
Checkpoint Kinase 1
DNA, Fungal
Enzyme Inhibitors
Protein Kinases
Schizosaccharomyces

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Schizosaccharomyces pombe Proteins

Topoisomerase I Inhibitors

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Identifiers

PMID: 10407262
DOI: 10.1002/(SICI)1097-0061(199907)15:10A<821::AID-YEA422>3.0.CO;2-#

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026. Prepared record publication-10407262-2026-08-31.1. Manifest publication-graph-cohort-2026-08-31.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 31 Aug 2026.

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The topoisomerase I poison camptothecin generates a Chk1-dependent DNA damage checkpoint signal in fission yeast.PMID 10407262Read ↗

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