Article

The activation loop residue serine 173 of <i>S.pombe</i> Chk1 kinase is critical for the response to DNA replication stress

2017-07-16

Abstract excerpt

Why the DNA damage checkpoint kinase Chk1 protects the genome of lower and higher eukaryotic cells differentially is still unclear. Mammalian Chk1 regulates replication origins, safeguards DNA replication forks and promotes fork progression. Conversely, yeast Chk1 acts only in G1 and G2. We report here that the mutation of serine 173 (S173A) in the activation loop of fission yeast Chk1 abolishes the G1-M and S-M c...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 64bd5a92-ec6a-5c40-8556-e17b86693934
DOI: 10.1101/164244

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The activation loop residue serine 173 of <i>S.pombe</i> Chk1 kinase is critical for the response to DNA replication stressDOI 10.1101/164244Read

Analysis of Rad3 and Chk1 protein kinases defines different checkpoint responses.Semantic proximity Read

Importance of a C-terminal conserved region of Chk1 for checkpoint function.Semantic proximity Read

Chk1 C-terminal regulatory phosphorylation mediates checkpoint activation by de-repression of Chk1 catalytic activity.Semantic proximity Read

Fission yeast chk1 mutants show distinct responses to different types of DNA damaging treatments.Semantic proximity Read

Interaction of 14-3-3 protein with Chk1 affects localization and checkpoint function.Semantic proximity Read

rad-dependent response of the chk1-encoded protein kinase at the DNA damage checkpoint.Semantic proximity Read

Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint.Semantic proximity Read

Inhibition of Chk1-dependent G2 DNA damage checkpoint radiosensitizes p53 mutant human cells.Semantic proximity Read

KA1-targeted regulatory domain mutations activate Chk1 in the absence of DNA damage.Semantic proximity Read

Rad17 phosphorylation is required for claspin recruitment and Chk1 activation in response to replication stress.Semantic proximity Read

Specific role of Chk1 phosphorylations in cell survival and checkpoint activation.Semantic proximity Read

A novel genetic screen identifies checkpoint-defective alleles of Schizosaccharomyces pombe chk1.Semantic proximity Read