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Fission yeast chk1 protein kinase links the rad checkpoint pathway to cdc2.

Nature - 27 May 1993

Walworth N, Davey S, Beach D

Abstract excerpt

The dependence of cell-cycle progression on the integrity of the genome has been described as checkpoint control. A number of mutants of the fission yeast Schizosaccharomyces pombe, selected for their sensitivity to DNA damage caused by radiation (rad mutants) or to the DNA synthesis inhibitor hy...

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Mutation
Molecular Sequence Data
Amino Acid Sequence
DNA-Binding Proteins
Restriction Mapping
Genes, Fungal

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Fungal Proteins

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PMID: 8497322
DOI: 10.1038/363368a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026. Prepared record publication-8497322-2026-08-31.1. Manifest publication-graph-cohort-2026-08-31.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 31 Aug 2026.

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Click a neighbor to travelStep 1 · 12 closest

Fission yeast chk1 protein kinase links the rad checkpoint pathway to cdc2.PMID 8497322Read ↗

p56(chk1) protein kinase is required for the DNA replication checkpoint at 37 degrees C in fission yeast.Semantic proximity Read ↗

Fission yeast chk1 mutants show distinct responses to different types of DNA damaging treatments.Semantic proximity Read ↗

Control of the DNA damage checkpoint by chk1 and rad53 protein kinases through distinct mechanisms.Semantic proximity Read ↗

rad-dependent response of the chk1-encoded protein kinase at the DNA damage checkpoint.Semantic proximity Read ↗

A novel genetic screen identifies checkpoint-defective alleles of Schizosaccharomyces pombe chk1.Semantic proximity Read ↗

Interaction of 14-3-3 protein with Chk1 affects localization and checkpoint function.Semantic proximity Read ↗

The chk1 pathway is required to prevent mitosis following cell-cycle arrest at 'start'.Semantic proximity Read ↗

Regulation of telomere length by checkpoint genes in Schizosaccharomyces pombe.Semantic proximity Read ↗

Identification and characterization of new elements involved in checkpoint and feedback controls in fission yeast.Semantic proximity Read ↗

The topoisomerase I poison camptothecin generates a Chk1-dependent DNA damage checkpoint signal in fission yeast.Semantic proximity Read ↗

Importance of a C-terminal conserved region of Chk1 for checkpoint function.Semantic proximity Read ↗

A fission yeast homolog of CDC20/p55CDC/Fizzy is required for recovery from DNA damage and genetically interacts with p34cdc2.Semantic proximity Read ↗

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