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Article

Fission yeast chk1 protein kinase links the rad checkpoint pathway to cdc2.

Nature - 27 May 1993

Walworth N, Davey S, Beach D

Abstract excerpt

The dependence of cell-cycle progression on the integrity of the genome has been described as checkpoint control. A number of mutants of the fission yeast Schizosaccharomyces pombe, selected for their sensitivity to DNA damage caused by radiation (rad mutants) or to the DNA synthesis inhibitor hydroxyurea (hus mutants) have been classified as checkpoint mutants because they fail to arrest the cell cycle in...

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PMID: 8497322
DOI: 10.1038/363368a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Fission yeast chk1 protein kinase links the rad checkpoint pathway to cdc2.PMID 8497322Read ↗

p56(chk1) protein kinase is required for the DNA replication checkpoint at 37 degrees C in fission yeast.Semantic proximity Read ↗

Fission yeast chk1 mutants show distinct responses to different types of DNA damaging treatments.Semantic proximity Read ↗

Control of the DNA damage checkpoint by chk1 and rad53 protein kinases through distinct mechanisms.Semantic proximity Read ↗

rad-dependent response of the chk1-encoded protein kinase at the DNA damage checkpoint.Semantic proximity Read ↗

A novel genetic screen identifies checkpoint-defective alleles of Schizosaccharomyces pombe chk1.Semantic proximity Read ↗

Interaction of 14-3-3 protein with Chk1 affects localization and checkpoint function.Semantic proximity Read ↗

The chk1 pathway is required to prevent mitosis following cell-cycle arrest at 'start'.Semantic proximity Read ↗

Regulation of telomere length by checkpoint genes in Schizosaccharomyces pombe.Semantic proximity Read ↗

Identification and characterization of new elements involved in checkpoint and feedback controls in fission yeast.Semantic proximity Read ↗

The topoisomerase I poison camptothecin generates a Chk1-dependent DNA damage checkpoint signal in fission yeast.Semantic proximity Read ↗

Importance of a C-terminal conserved region of Chk1 for checkpoint function.Semantic proximity Read ↗

A fission yeast homolog of CDC20/p55CDC/Fizzy is required for recovery from DNA damage and genetically interacts with p34cdc2.Semantic proximity Read ↗

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