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Article

rad-dependent response of the chk1-encoded protein kinase at the DNA damage checkpoint.

Science (New York, N.Y.) - 19 Jan 1996

Walworth N C, Bernards R

Abstract excerpt

Exposure of eukaryotic cells to agents that generate DNA damage results in transient arrest of progression through the cell cycle. In fission yeast, the DNA damage checkpoint associated with cell cycle arrest before mitosis requires the protein kinase p56chk1. DNA damage induced by ultraviolet light, gamma radiation, or a DNA-alkylating agent has now been shown to result in phosphorylation of p56chk1. This...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 8553071
DOI: 10.1126/science.271.5247.353

Genes

ATM
SDS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

rad-dependent response of the chk1-encoded protein kinase at the DNA damage checkpoint.PMID 8553071Read ↗

Analysis of Rad3 and Chk1 protein kinases defines different checkpoint responses.Semantic proximity Read ↗

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Interaction of 14-3-3 protein with Chk1 affects localization and checkpoint function.Semantic proximity Read ↗

A novel genetic screen identifies checkpoint-defective alleles of Schizosaccharomyces pombe chk1.Semantic proximity Read ↗

Control of the DNA damage checkpoint by chk1 and rad53 protein kinases through distinct mechanisms.Semantic proximity Read ↗

A phospho-proteomic screen identifies substrates of the checkpoint kinase Chk1Semantic proximity Read ↗

Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent Phosphorylation of Chk1 on Ser-317 in Response to Ionizing RadiationSemantic proximity Read ↗

The topoisomerase I poison camptothecin generates a Chk1-dependent DNA damage checkpoint signal in fission yeast.Semantic proximity Read ↗

Pds1 phosphorylation in response to DNA damage is essential for its DNA damage checkpoint function.Semantic proximity Read ↗

The Chk2 protein kinase.Semantic proximity Read ↗

Fission yeast chk1 mutants show distinct responses to different types of DNA damaging treatments.Semantic proximity Read ↗

Importance of a C-terminal conserved region of Chk1 for checkpoint function.Semantic proximity Read ↗

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