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Article

Glu298Asp endothelial nitric oxide synthase gene polymorphism interacts with environmental and dietary factors to influence endothelial function.

Circulation research - 14 Jun 2002

Leeson C P M, Hingorani A D, Mullen M J, Jeerooburkhan N, Kattenhorn M, Cole T J, Muller D P R, Lucas A, Humphries S E, Deanfield J E

Abstract excerpt

An endothelial nitric oxide synthase (eNOS) gene polymorphism (Glu298Asp) has been associated with cardiovascular disease. We investigated whether carriage of the polymorphism was associated with functional changes in the endothelium, and how genotype altered the harmful and beneficial impact of environmental influences on the endothelium. Endothelium-dependent, flow-mediated brachial artery dilatation (FMD) and...

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Identifiers

PMID: 12065317
DOI: 10.1161/01.res.0000020562.07492.d4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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