Article
Functional gene testing of the Glu298Asp polymorphism of the endothelial NO synthase.
Journal of hypertension - 1 Dec 2000
Schneider M P, Erdmann J, Delles C, Fleck E, Regitz-Zagrosek V, Schmieder R E
Abstract excerpt
OBJECTIVES: To test whether the Glu298Asp polymorphism of the endothelial nitric oxide synthase (eNOS) gene is of functional relevance in humans by altering endothelium-dependent vasodilation. BACKGROUND: The Asp298 variant of the eNOS gene product has been associated with arterial hypertension, coronary artery disease and myocardial infarction. The pathogenetic mechanism has not yet been elucidated. Since...
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