Article
Endothelial nitric oxide synthase and methylenetetrahydrofolate reductase gene polymorphisms are associated with endothelial dysfunction in young, healthy men.
The Canadian journal of cardiology - 1 Oct 2004
Imamura Akiko, Okumura Kenji, Matsui Hideo, Mizuno Tomofumi, Ogawa Yasuhiro, Imai Hajime, Numaguchi Yasushi, Sakai Kazuyoshi, Murohara Toyoaki
Abstract excerpt
BACKGROUND: The guanine to thymine polymorphism at position 894 of the eNOS gene (resulting in a change from glutamate to aspartate [Asp] at codon 298 [Asp298]) and the methylenetetrahydrofolate reductase (MTHFR) gene polymorphism (C677T) have been reported to be associated with atherosclerosis and cardiovascular disease. Endothelial dysfunction is considered to be the earliest stage of atherosclerosis....
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