Article
In-vivo effects of Glu298Asp endothelial nitric oxide synthase polymorphism.
Pharmacogenetics - 1 Dec 2001
Sofowora G, Dishy V, Xie H G, Imamura H, Nishimi Y, Morales C R, Morrow J D, Kim R B, Stein C M, Wood A J
Abstract excerpt
Endothelial nitric oxide synthase catalyses the formation of the vasodilator nitric oxide, a major regulator of vascular tone. The Asp298 polymorphism of the nitric oxide synthase gene is associated with altered function and expression of the enzyme in vitro and myocardial infarction and coronary artery spasm in vivo. We examined the effect of the Glu298Asp polymorphism on: (1) local vascular responses to...
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