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Article

Endothelial nitric oxide synthase gene polymorphism and maternal vascular adaptation to pregnancy.

Hypertension (Dallas, Tex. : 1979) - 1 Dec 2001

Savvidou M D, Vallance P J, Nicolaides K H, Hingorani A D

Abstract excerpt

A common polymorphism of the endothelial NO synthase gene that predicts a Glu298Asp amino acid substitution in the mature protein has been associated with cardiovascular disorders in which NO bioactivity is impaired. However, the influence of this polymorphism on endothelial function is unknown. Healthy pregnancy is associated with enhanced endothelium-dependent, flow-mediated dilation (FMD) of the brachial...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 11751705
DOI: 10.1161/hy1201.097305

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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