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Article

Somatic cell mutation in pediatric patients undergoing allogeneic bone marrow transplantation.

Mutation research - 27 May 2002

Hamahata Keigo, Kubota Masaru, Usami Ikuya, Lin Ying-Wei, Shimizu Ken, Morimoto Akira, Nakahata Tatsutoshi

Abstract excerpt

In order to examine whether bone marrow transplantation (BMT) has genotoxic effects in vivo, mutant frequencies (Mfs) at the hypoxanthine-guanine phosphoribosyl transferase (Hprt) locus were evaluated. Thirty-seven pediatric patients who had received allogeneic BMT for various hematologic or immunologic disorders were enrolled. Nine out of the 37 patients (24.3%) were found to have Hprt-Mfs exceeding the 99%...

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Identifiers

PMID: 12034305
DOI: 10.1016/s1383-5718(02)00023-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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