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Article

Somatic cell gene mutations in humans: biomarkers for genotoxicity.

Environmental health perspectives - 1 Oct 1993

Albertini R J, Nicklas J A, O'Neill J P

Abstract excerpt

Somatic cell gene mutations arising in vivo in humans provide biomarkers for genotoxicity. Four assays, each measuring changes in a different "recorder" gene, are available for detecting mutations of the hemoglobin (Hb) and glycophorin A (gpa) genes in red blood cells and the hypoxanthine-guanine phosphoribosyltransferase (hprt) and HLA genes in T-lymphocytes. Mean adult background mutant frequencies have been...

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Identifiers

PMID: 8143616
DOI: 10.1289/ehp.93101s3193
PMCID: PMC1521126

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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