Measurement of mutation frequency at the HPRT locus in peripheral lymphocytes. Is this a good method to evaluate a cancer risk in pediatric patients?

doi:10.1007/978-1-4615-5381-6_132

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Article

Measurement of mutation frequency at the HPRT locus in peripheral lymphocytes. Is this a good method to evaluate a cancer risk in pediatric patients?

Advances in experimental medicine and biology - 1 Jan 1998

Lin Y W, Kubota M, Akiyama Y, Sawada M, Furusho K

Abstract excerpt

Validity of measurement of somatic cell mutation frequency (Mf) at the hprt locus for evaluating cancer risk of the given individual was determined in pediatric patients. Peripheral lymphocytes (PL) from patients with various diseases, including acute lymphoblastic leukemia (ALL) and Hodgkin's di...

Topics

Adolescent
Adult
Antineoplastic Combined Chemotherapy Protocols
Child
Child, Preschool
Cockayne Syndrome
DNA Damage
DNA Repair
Hodgkin Disease
Human Growth Hormone
Humans
Hypoxanthine Phosphoribosyltransferase
Infant
Lymphocytes
Mutation
Neoplasms
Neoplasms, Second Primary
Precursor Cell Lymphoblastic Leukemia-Lymphoma

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Identifiers

PMID: 9598152
DOI: 10.1007/978-1-4615-5381-6_132

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9598152-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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