Article
Association study of candidate DNA-repair gene variants and acute graft versus host disease in pediatric patients receiving allogeneic hematopoietic stem-cell transplantation.
The pharmacogenomics journal - 1 Feb 2022
Uppugunduri C R S, Huezo-Diaz Curtis P, Nava T, Rezgui M A, Mlakar V, Mlakar S Jurkovic, Waespe N, Théoret Y, Gumy-Pause F, Bernard F, Chalandon Y, Boelens J J, Bredius R G M, Dalle J H, Nath C, Corbacioglu S, Peters C, Bader P, Shaw P, Bittencourt H, Krajinovic M, Ansari M
Abstract excerpt
Acute Graft versus Host Disease (aGvHD) grades 2-4 occurs in 15-60% of pediatric patients undergoing allogeneic haematopoietic stem-cell transplantation (allo-HSCT). The collateral damage to normal tissue by conditioning regimens administered prior to allo-HSCT serve as an initial trigger for aGvHD. DNA-repair mechanisms may play an important role in mitigating this initial damage, and so the variants in...
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