Genotoxicity of therapeutic intervention in children with acute lymphocytic leukemia.

doi:10.1158/0008-5472.CAN-03-3940

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Article

Genotoxicity of therapeutic intervention in children with acute lymphocytic leukemia.

Cancer research - 1 Jul 2004

Rice Sederick C, Vacek Pamela, Homans Alan H, Messier Terri, Rivers Jami, Kendall Heather, Finette Barry A

Abstract excerpt

The survival rates of children treated for cancer have dramatically increased after the development of standardized multiple-modality treatment protocols. As a result, there is a rapidly growing population of pediatric cancer survivors in which the long-term genotoxic effects of chemotherapeutic intervention is unknown. To study the genotoxic effects of antineoplastic treatment in children, we performed a...

Topics

Adolescent
Adult
Antineoplastic Agents
Child
Child, Preschool
Female
Genes, Reporter
Humans
Hypoxanthine Phosphoribosyltransferase
Infant
Longitudinal Studies
Male
Mutation
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Regression Analysis
Risk Factors

Source

Open in PubMed

Identifiers

PMID: 15231655
DOI: 10.1158/0008-5472.CAN-03-3940

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