Article
Analysis of hprt gene mutation following anti-cancer treatment in pediatric patients with acute leukemia.
Mutation research - 1 Oct 1993
Hirota H, Kubota M, Hashimoto H, Adachi S, Matsubara K, Kuwakado K, Akiyama Y, Tsutsui T, Mikawa H
Abstract excerpt
We evaluated the genotoxic effect of cancer therapy on somatic cell mutation by isolating 6-thioguanine-resistant mutants in peripheral lymphocytes. The study population comprised 45 children with acute lymphoblastic leukemia (ALL), 13 children with acute myelogenous leukemia (AML) and 28 age-mat...
Topics
- Adolescent
- Adult
- Antineoplastic Agents
- Blotting, Southern
- Child
- Child, Preschool
- Humans
- Hypoxanthine Phosphoribosyltransferase
- Infant
- Leukemia, Myeloid, Acute
- Mutation
- Precursor Cell Lymphoblastic Leukemia-Lymphoma