Article
Analysis of hprt gene mutation following anti-cancer treatment in pediatric patients with acute leukemia.
Mutation research - 1 Oct 1993
Hirota H, Kubota M, Hashimoto H, Adachi S, Matsubara K, Kuwakado K, Akiyama Y, Tsutsui T, Mikawa H
Abstract excerpt
We evaluated the genotoxic effect of cancer therapy on somatic cell mutation by isolating 6-thioguanine-resistant mutants in peripheral lymphocytes. The study population comprised 45 children with acute lymphoblastic leukemia (ALL), 13 children with acute myelogenous leukemia (AML) and 28 age-matched healthy controls. The geometric mean mutant frequency for ALL patients was 7.8 x 10(-6), which was significantly...
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