Article
HPRT mutations in vivo in human CD 34+ hematopoietic stem cells.
Mutation research - 17 Dec 1999
Grant B W, Trombley L M, Hunter T C, Nicklas J A, O'Neill J P, Albertini R J
Abstract excerpt
The HPRT mutations in T lymphocytes are widely utilized as biomarkers of environmental exposure and effect. The HPRT gene detects a wide variety of mutation types, many of which are similar at the molecular level to those found in oncogenes in cancers. However, it remains to be determined whether the assay for mutations in T lymphocytes is reflective of mutagenic events in tissues or cells which have high...
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