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Article

Computational stabilization of human growth hormone.

Protein science : a publication of the Protein Society - 1 Jun 2002

Filikov Anton V, Hayes Robert J, Luo Peizhi, Stark Diane M, Chan Cheryl, Kundu Anirban, Dahiyat Bassil I

Abstract excerpt

Recombinant human growth hormone (hGH) is used worldwide for the treatment of pediatric hypopituitary dwarfism and in children suffering from low levels of hGH. It has limited stability in solution, and because of poor oral absorption, is administered by injection, typically several times a week. Development has therefore focused on more stable or sustained-release formulations and alternatives to injectable...

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Identifiers

PMID: 12021444
DOI: 10.1110/ps.3500102
PMCID: PMC2373623

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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