Article

Amino acid substitutions in human growth hormone affect coiled-coil content and receptor binding

2021-12-17

Abstract excerpt

The interaction between human Growth Hormone (hGH) and hGH Receptor (hGHR) has great relevance to human diseases such as acromegaly and cancer. HGH has been extensively engineered by other workers to improve binding and other properties. We used a computational screen to select substitutions at single hGH positions within the hGHR-binding site. We find that, while many successfully slow down dissociation of the hG...

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Literature Corpus work: 4f177760-cbff-5d42-8a83-0a4de57827b0
DOI: 10.1101/2021.12.16.473085

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