Article

Structural and Evolutionary Analysis of Human Growth Hormone Variants

2025-03-19

Abstract excerpt

Human growth hormone (GH) exerts its pleiotropic effects by binding to its receptor (GHR), leading to receptor dimerization and activation. We combined structural, evolutionary, and genetic analyses to elucidate the critical determinants of GH-GHR interaction and the impact of disease-causing mutations. Protein contact analysis revealed the specific amino acid residues involved in two distinct binding interfaces b...

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Literature Corpus work: cd4dbe57-9289-57f0-9c01-3e5602f3b26f
DOI: 10.1101/2025.03.19.644177

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