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Article

Structural basis for activation of the growth hormone-releasing hormone receptor.

Nature communications - 15 Oct 2020

Zhou Fulai, Zhang Huibing, Cong Zhaotong, Zhao Li-Hua, Zhou Qingtong, Mao Chunyou, Cheng Xi, Shen Dan-Dan, Cai Xiaoqing, Ma Cheng, Wang Yuzhe, Dai Antao, Zhou Yan, Sun Wen, Zhao Fenghui, Zhao Suwen, Jiang Hualiang, Jiang Yi, Yang Dehua, Eric Xu H, Zhang Yan, Wang Ming-Wei

Abstract excerpt

Growth hormone-releasing hormone (GHRH) regulates the secretion of growth hormone that virtually controls metabolism and growth of every tissue through its binding to the cognate receptor (GHRHR). Malfunction in GHRHR signaling is associated with abnormal growth, making GHRHR an attractive therapeutic target against dwarfism (e.g., isolated growth hormone deficiency, IGHD), gigantism, lipodystrophy and certain...

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Identifiers

PMID: 33060564
DOI: 10.1038/s41467-020-18945-0
PMCID: PMC7567103

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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