Article
Development of a cytokine analog with enhanced stability using computational ultrahigh throughput screening.
Protein science : a publication of the Protein Society - 1 May 2002
Luo Peizhi, Hayes Robert J, Chan Cheryl, Stark Diane M, Hwang Marian Y, Jacinto Jonathan M, Juvvadi Padmaja, Chung Helen S, Kundu Anirban, Ary Marie L, Dahiyat Bassil I
Abstract excerpt
Granulocyte-colony stimulating factor (G-CSF) is used worldwide to prevent neutropenia caused by high-dose chemotherapy. It has limited stability, strict formulation and storage requirements, and because of poor oral absorption must be administered by injection (typically daily). Thus, there is significant interest in developing analogs with improved pharmacological properties. We used our ultrahigh throughput...
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