Optimized clinical performance of growth hormone with an expanded genetic code.

doi:10.1073/pnas.1100387108

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Article

Optimized clinical performance of growth hormone with an expanded genetic code.

Proceedings of the National Academy of Sciences of the United States of America - 31 May 2011

Cho Ho, Daniel Tom, Buechler Ying Ji, Litzinger David C, Maio Zhenwei, Putnam Anna-Maria Hays, Kraynov Vadim S, Sim Bee-Cheng, Bussell Stuart, Javahishvili Tsotne, Kaphle Sami, Viramontes Guillermo, Ong Mike, Chu Stephanie, Becky G C, Lieu Ricky, Knudsen Nick, Castiglioni Paola, Norman Thea C, Axelrod Douglas W, Hoffman Andrew R, Schultz Peter G, DiMarchi Richard D, Kimmel Bruce E

Abstract excerpt

The ribosomal incorporation of nonnative amino acids into polypeptides in living cells provides the opportunity to endow therapeutic proteins with unique pharmacological properties. We report here the first clinical study of a biosynthetic protein produced using an expanded genetic code. Incorporation of p-acetylphenylalanine (pAcF) at distinct locations in human growth hormone (hGH) allowed site-specific...

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Identifiers

PMID: 21576502
DOI: 10.1073/pnas.1100387108
PMCID: PMC3107295

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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