Article

Mapping the Functional Epitopes of Human Growth Hormone: Integrating Structural and Evolutionary Data with Clinical Variants

2025-03-20

Abstract excerpt

Human growth hormone (GH) exerts its pleiotropic effects by binding to its receptor (GHR), leading to receptor dimerization and activation. We combined structural, evolutionary, and genetic analyses to elucidate the critical determinants of GH-GHR interaction and the impact of disease-causing mutations. Protein contact analysis revealed the specific amino acid residues involved in two distinct binding interfaces b...

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Literature Corpus work: 2d08915e-578e-5f55-9a8d-143dc6595cac
DOI: 10.20944/preprints202503.1553.v1

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