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A novel peptide antagonist of the human growth hormone receptor

1 Jan 2021

Abstract excerpt

Excess circulating human growth hormone (hGH) in vivo is linked to metabolic and growth disorders such as cancer, diabetes, and acromegaly. Consequently, there is considerable interest in developing antagonists of hGH action. Here, we present the design, synthesis, and characterization of a 16-residue peptide (site 1-binding helix [S1H]) that inhibits hGH-mediated STAT5 phosphorylation in cultured cells. S1H was...

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PMID: 33774052
DOI: 10.1016/j.jbc.2021.100588

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