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Article

The role of human growth hormone's C-terminal disulfide bridge.

Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society - 1 Jun 2013

Junnila R K, Wu Z, Strasburger C J

Abstract excerpt

OBJECTIVE: Human growth hormone (hGH), as well as the other members of the same polypeptide hormone family, have a four-helix bundle structure linked by two disulfide bridges, C53-C165 and C182-C189 in hGH. The C-terminal disulfide bridge of growth hormone is evolutionally conserved but its role is unknown. Our aim was to determine its importance for GH structure and/or function. DESIGN: We disrupted the highly...

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Source

Identifiers

PMID: 23478141
DOI: 10.1016/j.ghir.2013.02.002

Genes

GHR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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