Article
Molecular epidemiology of VHL gene mutations in renal cell carcinoma patients: relation to dietary and other factors.
Carcinogenesis - 1 May 2002
Hemminki Kari, Jiang Yongwen, Ma Xin, Yang Ke, Egevad Lars, Lindblad Per
Abstract excerpt
Carcinogenic chemicals act through DNA damage and mitogenic effects. No established mechanism explains the cancer preventive effects, if any, of food items, such as vegetables and fruit. If such data were available, preferably on tumor-initiating genes, the evidence for the protective effects would become stronger. The von Hipple-Lindau (VHL) gene is the tumor suppressor gene predisposing to both sporadic renal...
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