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Article

Prevalence of von Hippel-Lindau gene mutations in sporadic renal cell carcinoma: results from The Netherlands cohort study.

BMC cancer - 2 Jun 2005

van Houwelingen Kjeld P, van Dijk Boukje A C, Hulsbergen-van de Kaa Christina A, Schouten Leo J, Gorissen Hanneke J M, Schalken Jack A, van den Brandt Piet A, Oosterwijk Egbert

Abstract excerpt

BACKGROUND: Biallelic von Hippel-Lindau (VHL) gene defects, a rate-limiting event in the carcinogenesis, occur in approximately 75% of sporadic clear-cell Renal Cell Carcinoma (RCC). We studied the VHL mutation status in a large population-based case group. METHODS: Cases were identified within the Netherlands cohort study on diet and cancer, which includes 120,852 men and women. After 11.3 years of follow-up,...

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Identifiers

PMID: 15932632
DOI: 10.1186/1471-2407-5-57
PMCID: PMC1177929

Genes

VHL

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Prevalence of von Hippel-Lindau gene mutations in sporadic renal cell carcinoma: results from The Netherlands cohort study.PMID 15932632Read ↗

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