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Article

Germline polymorphisms in the Von Hippel-Lindau and Hypoxia-inducible factor 1-alpha genes, gene-environment and gene-gene interactions and renal cell cancer.

Scientific reports - 10 Jan 2020

van de Pol Jeroen A A, van den Brandt Piet A, van Engeland Manon, Godschalk Roger W L, van Schooten Frederik-Jan, Hogervorst Janneke G F, Schouten Leo J

Abstract excerpt

We investigated the relationship between germline single nucleotide polymorphisms (SNPs) in Von Hippel-Lindau (VHL) and Hypoxia-inducible factor 1-alpha (HIF1A), and their gene-environment and gene-gene interactions, and clear-cell RCC (ccRCC) risk. Furthermore, we assessed the relationship between VHL SNPs and VHL promoter methylation. Three VHL polymorphisms and one HIF1A polymorphism were genotyped in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Hypoxia-Inducible Factor 1, alpha Subunit

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Source

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Identifiers

PMID: 31924838
DOI: 10.1038/s41598-019-56980-0
PMCID: PMC6954183

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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