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Article

Genetic and epigenetic alterations in the von hippel-lindau gene: the influence on renal cancer prognosis.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Feb 2008

Smits Kim M, Schouten Leo J, van Dijk Boukje A C, Hulsbergen-van de Kaa Christina A, Wouters Kim A D, Oosterwijk Egbert, van Engeland Manon, van den Brandt Piet A

Abstract excerpt

BACKGROUND: Inactivation of the von Hippel-Lindau (VHL) gene is considered as an early event in renal cancer tumorigenesis. The prognostic relevance of these changes, however, is not clear and previous results are contradictory. We have evaluated the influence of (epi)genetic alterations in VHL on cause-specific survival in clear-cell renal cell cancer (ccRCC) in a large, population-based group of cases. METHODS:...

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Source

Identifiers

PMID: 18245539
DOI: 10.1158/1078-0432.CCR-07-1753

Genes

VHL

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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