Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Relation of three polymorphisms of the CTLA-4 gene in patients with Graves' disease.

Journal of endocrinological investigation - 1 Mar 2002

Kouki T, Gardine C A, Yanagawa T, Degroot L J

Abstract excerpt

Graves' disease is an autoimmune disease believed to be caused by a combination of environmental and genetic factors. One of the candidate genes is CTLA-4, a negative regulator of T cell activation. Three polymorphisms of the gene have been described, in the promoter at position -318, at position 49 in exon 1, and an (AT)n repeat within the 3'-untranslated region of exon 4. Many studies describe the association...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Abatacept
Share to Antigens, CD
Share to Antigens, Differentiation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Autoimmune Diseases

Share to Autoradiography

Share to CTLA-4 Antigen

Share to Graves Disease

Share to Immunoconjugates

Source

Identifiers

PMID: 11936461
DOI: 10.1007/BF03343992

Genes

CTLA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Relation of three polymorphisms of the CTLA-4 gene in patients with Graves' disease.PMID 11936461Read ↗

CTLA4 gene polymorphism confers susceptibility to Graves' disease in Japanese.Semantic proximity Read ↗

CTLA-4 gene polymorphism associated with Graves' disease in a Caucasian population.Semantic proximity Read ↗

Association of CTLA-4 gene polymorphism with Graves' disease and ophthalmopathy in Iranian patients.Semantic proximity Read ↗

CTLA4 gene and Graves’ disease: association of Graves’ disease with the CTLA4 exon 1 and intron 1 polymorphisms, but not with the promoter polymorphismSemantic proximity Read ↗

CTLA-4 gene polymorphisms in Tunisian patients with Graves' disease.Semantic proximity Read ↗

The genetics of Graves' disease.Semantic proximity Read ↗

Meta-Analysis of CTLA-4 +49 Gene Polymorphism and Susceptibility to Graves' Disease.Semantic proximity Read ↗

The Development of Graves' Disease and the CTLA-4 Gene on Chromosome 2q33Semantic proximity Read ↗

The cytotoxic T lymphocyte antigen-4 is a major Graves' disease locusSemantic proximity Read ↗

The development of Graves' disease and the CTLA-4 gene on chromosome 2q33.Semantic proximity Read ↗

Association of the CTLA4 gene with Graves' disease in the Chinese Han population.Semantic proximity Read ↗

CTLA-4 gene polymorphism at position 49 in exon 1 reduces the inhibitory function of CTLA-4 and contributes to the pathogenesis of Graves' disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.