Article
The development of Graves' disease and the CTLA-4 gene on chromosome 2q33.
The Journal of clinical endocrinology and metabolism - 1 Jul 1999
Heward J M, Allahabadia A, Armitage M, Hattersley A, Dodson P M, Macleod K, Carr-Smith J, Daykin J, Daly A, Sheppard M C, Holder R L, Barnett A H, Franklyn J A, Gough S C
Abstract excerpt
Case-control studies suggest that the CTLA-4 gene may be a susceptibility locus for Graves' disease. The previously reported A/G polymorphism at position 49 in exon 1 of the CTLA-4 gene was, therefore, investigated in a case-control (n = 743) and family-based (n = 179) dataset of white Caucasian subjects with Graves' disease. The relationship between CTLA-4 genotype and severity of thyroid dysfunction at...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.