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Article

The cytotoxic T lymphocyte antigen-4 is a major Graves' disease locus

1 Jul 1999

Abstract excerpt

Graves' disease (GD) is an autoimmune thyroid disorder that is inherited as a complex trait. We have genotyped 77 affected sib-pairs with autoimmune thyroid disease for eight polymorphic markers spanning the cytotoxic T lymphocyte antigen-4 ( CTLA-4 ) region of chromosome 2q31-q33, and for five markers spanning the major histocompatibility complex ( MHC ) region of chromosome 6p21. Non-parametric analysis showed...

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Identifiers

PMID: 10369864
DOI: 10.1093/hmg/8.7.1195

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Source receipt: pubmed, retrieved 7 Sept 2026.

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