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Article

CTLA-4 gene polymorphism at position 49 in exon 1 reduces the inhibitory function of CTLA-4 and contributes to the pathogenesis of Graves' disease.

Journal of immunology (Baltimore, Md. : 1950) - 1 Dec 2000

Kouki T, Sawai Y, Gardine C A, Fisfalen M E, Alegre M L, DeGroot L J

Abstract excerpt

Activation of T cells requires at least two signals transduced by the Ag-specific TCR and a costimulatory ligand such as CD28. CTLA-4, expressed on activated T cells, binds to B7 present on APCs and functions as a negative regulator of T cell activation. Our laboratory previously reported the association of Graves' disease (GD) with a specific CTLA-4 gene polymorphism. In theory, reduced expression or function of...

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Source

Identifiers

PMID: 11086105
DOI: 10.4049/jimmunol.165.11.6606

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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