CTLA4 gene polymorphism confers susceptibility to Graves' disease in Japanese.

doi:10.1089/thy.1997.7.843

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Article

CTLA4 gene polymorphism confers susceptibility to Graves' disease in Japanese.

Thyroid : official journal of the American Thyroid Association - 1 Dec 1997

Yanagawa T, Taniyama M, Enomoto S, Gomi K, Maruyama H, Ban Y, Saruta T

Abstract excerpt

Susceptibility to Graves' disease (GD) is determined by environmental and genetic factors. The genetic susceptibility to GD is conferred by genes in the human leukocyte antigen (HLA), and several other genes unlinked to HLA are thought to contribute to the development of GD. Three recent papers described the association of GD with the CTLA-4 gene. CTLA-4 is a candidate gene for T-cell mediated autoimmune diseases...

Topics

Abatacept
Antigens, CD
Antigens, Differentiation
CTLA-4 Antigen
Data Interpretation, Statistical
Female
Gene Frequency
Genes
Genetic Predisposition to Disease
Genotype
Graves Disease
Humans
Immunoconjugates
Japan
Male
Polymorphism, Genetic
Sex Factors

Source

Open in PubMed

Identifiers

PMID: 9459626
DOI: 10.1089/thy.1997.7.843

Genes

CTLA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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