CTLA-4 gene polymorphisms in Tunisian patients with Graves' disease.

doi:10.1006/clim.2001.5121

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Article

CTLA-4 gene polymorphisms in Tunisian patients with Graves' disease.

Clinical immunology (Orlando, Fla.) - 1 Dec 2001

Hadj Kacem H, Bellassoued M, Bougacha-Elleuch N, Abid M, Ayadi H

Abstract excerpt

Graves' disease (GD) is an organ-specific autoimmune disorder of multifactorial etiology with a polygenic mode of inheritance. A recent report has demonstrated that there is a linkage and an association between the genetic markers of the CTLA-4 gene on chromosome 2q33 and GD. In order to confirm this association in a Tunisian population, three polymorphisms of the CTLA-4 gene were analyzed: the first is at the...

Topics

Abatacept
Alleles
Antigens, CD
Antigens, Differentiation
CTLA-4 Antigen
Chromosomes, Human, Pair 2
Female
Genetic Markers
Genetic Predisposition to Disease
Graves Disease
Humans
Immunoconjugates
Male
Polymorphism, Genetic
Tunisia

Source

Open in PubMed

Identifiers

PMID: 11726229
DOI: 10.1006/clim.2001.5121

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