Article
CTLA-4 gene polymorphisms in Tunisian patients with Graves' disease.
Clinical immunology (Orlando, Fla.) - 1 Dec 2001
Hadj Kacem H, Bellassoued M, Bougacha-Elleuch N, Abid M, Ayadi H
Abstract excerpt
Graves' disease (GD) is an organ-specific autoimmune disorder of multifactorial etiology with a polygenic mode of inheritance. A recent report has demonstrated that there is a linkage and an association between the genetic markers of the CTLA-4 gene on chromosome 2q33 and GD. In order to confirm this association in a Tunisian population, three polymorphisms of the CTLA-4 gene were analyzed: the first is at the...
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